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no you cannot but For example, this error occurs if you have a mix of Server Core and full installations of Windows Server 2008 in a failover cluster.
Posted by waqasahmad
No you can't
Posted by HamidAliKhan
No, you can’t mix full and server core installations in one cluster. If you run the Validate a Configuration action from the Microsoft Management Console (MMC) Failover Cluster Management snap-in, it will fail the Validate Operating System Versions check. The action’s report will state that you cannot mix full and core installations, as the following screen.
Posted by mariuspaul